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First report to describe the inflammatory reflex and demonstrate the effect of electrical vagus nerve stimulation in reducing systemic inflammation
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Electrical vagus nerve stimulation reduces trafficking of inflammatory cells to the intestine
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Vagotomy worsens and pharmacologic agonists improve disease severity in a standard murine model of colitis.
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An intact signaling pathway between the vagus nerve, splenic nerve and spleen is critical in mediating the effect of the inflammatory reflex in reducing inflammation in endotoxemia
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Description of a novel splenic T cell population that mediates the inflammatory reflex by bridging signals between the splenic nerve and splenic macrophages
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Pharmacologic activation of the inflammatory reflex reduces and vagotomy worsens disease severity in a standard rodent arthritis model
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Blockade of the inflammatory reflex in nicotinic acetylcholine receptor a7 subunit gene knockout mice is associated with worsened disease in a murine arthritis model
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First demonstration that the inflammatory reflex acts through the alpha 7 nicotinic acetylcholine receptor
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Demonstration of sustained reduction of systemic inflammatory markers in response to vagus nerve stimulation in a chronic congestive heart failure model
Sun P, et al. Involvement of MAPK/NF-κB signaling in the activation of the cholinergic anti-inflammatory pathway in experimental colitis by chronic vagus nerve stimulation. PLoS One 2013; 8:e69424. (http://www.ncbi.nlm.nih.gov/pubmed/23936328)
Efficacy of electrical vagus nerve stimulation is demonstrated in a standard rodent colitis model of inflammatory bowel disease.
Inflammation plays a significant role in acute and chronic diseases including rheumatoid arthritis (RA), inflammatory bowel disease (IBD), psoriasis, diabetes, heart disease, and multiple sclerosis.