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TRANSFORM THE TREATMENT OF RHEUMATOID ARTHRITIS

Introducing setpoint therapy

A revolutionary new treatment for rheumatoid arthritis

The convergence of extraordinary advances in immunology, neuroscience, and engineering have resulted in the development of an entirely new treatment approach for rheumatoid arthritis: Neuroimmune Modulation. This device-based therapeutic approach includes a small, wireless, implantable device, the SetPoint System, that stimulates the vagus nerve—activating the body’s innate pathways to reduce inflammation and restore immunologic balance. 1-3

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The SetPoint Advantage

You're implanted, your little scar heals, and you're done.
~Lynn, North Carolina. RESET-RA study participant.
Actual patient stories shared with their permission. Individual outcomes vary.
People, much like myself, will be really excited about SetPoint when they hear the science behind it, and when they see the 10 years of research that has gone into it.
~Dr. Angela Crowley, Rheumatologist
Since the SetPoint Implant, I don't think about my RA like I used to. It's not the main concern of my day anymore.
~Bridgette, Arizona. RESET-RA study participant.
Actual patient stories shared with their permission. Individual outcomes vary.
You're implanted, your little scar heals, and you're done. You're not injecting chemicals into your body every week, every two weeks for the rest of your life.
~Lynn, SetPoint patient
You're implanted, your little scar heals, and you're done. You're not injecting chemicals into your body every week, every two weeks for the rest of your life.
~Lynn, SetPoint patient
People, much like myself, will be really excited about SetPoint when they hear the science behind it, and when they see the 10 years of research that's gone into it.
~Dr. Angela Crowley, Rheumatologist, Willowbrook, IL
People, much like myself, will be really excited about SetPoint when they hear the science behind it, and when they see the 10 years of research that's gone into it.
~Dr. Bridgette, SetPoint patient
60%
average improvement in tender and swollen joint counts observed over 12 months with SetPoint Therapy
9 of 10
Participants in the RESET-RA study stated they would recommend SetPoint Therapy to their family or friends for treatment of RA

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1. Tracey KJ. The inflammatory reflex. Nature. 2002;420(6917):853-859.
2. van Maanen MA, et al. The cholinergic anti-inflammatory pathway: towards innovative treatment of rheumatoid arthritis. Nat Rev Rheumatol. 2009;5(4):229-232.
3. Kelly MJ, et al. Manipulation of the inflammatory reflex as a therapeutic strategy. Cell Rep Med. 2022;3(7):100696.
4. Peterson D, et al. Clinical safety and feasibility of a novel implantable neuroimmune modulation device for the treatment of rheumatoid arthritis: initial results from the randomized, double-blind, sham-controlled RESET-RA study. Bioelectron Med. 2024;10(1):8.
5. Data on file at SetPoint Medical